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KMID : 0357920070410060387
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Korean Journal of Pathology
2007 Volume.41 No. 6 p.387 ~ p.392
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Clinicopathologic Analysis of Epidermal Growth Factor Receptor Status in Non-small Cell Lung Cancer: Protein Expression, Gene Amplification and Survival Analysis
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Lee Sung-Koo
Choi Jene
Jang Se-Jin
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Abstract
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Background : Abnormal over-expression or gene amplification of epidermal growth factor receptor (EGFR) is important in the prognosis of non-small cell lung cancer (NSCLC). We investigated the frequency of EGFR protein expression and gene amplification, and the correlation between EGFR status and survival in NSCLC.
Methods : We examined 360 cases of microarrayed NSCLC tissues for the EGFR protein expression and EGFR gene amplification using immunohistochemistry and fluorescent in situ hybridization.
Results : EGFR protein expression and EGFR gene amplification occurred in 110 cases (30.6%) and 24 cases
(6.7%), respectively. EGFR prote in expression and gene amplification were more frequent in squamous cell carcinoma than in adenocarcinoma. Differences in EGFR protein expression did not dramatically affect survival curves (p=0.740), but differences in gene amplification did (p<0.05): EGFR gene amplification was associated with a lower 5-year survival rate.
Conclusion : EGFR protein expression and gene amplification showed moderate correlation with each other. EGFR gene amplification predicted a poor prognosis, whereas EGFR protein expression did not.
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KEYWORD
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Carcinoma, Non-small-cell lung, Receptor, Epidermal growth factor, In situ hybridization
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